Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been described as potential blood-derived inflammatory biomarkers in several diseases. Rheumatoid arthritis is an disease that has related to increased risk of cardiovascular (CV) disease. In the present work, we analyze how these hematological composite scores inflammation are classic CV factors subclinical atherosclerosis patients with RA. this cross-sectional study included 430 RA, NLR, MLR, PLR, SIRI were calculated. Multivariable analysis was performed examine relationships blood carotid traditional factors, producing a complete profile lipid molecules insulin resistance or indices beta-cell function, Systematic Coronary Risk Assessment (SCORE2) calculation. C-reactive protein activity significantly positively associated four scores. SCORE2 higher values SIRI, but not PLR. These maintained when SCORE 2 considered categorical; very high category had all scores, except multivariable analysis, NLR independently levels beta cell dysfunction. conclusion, correlated addition, there some their association dysfunction being most consistent.